Patho-Phyisology of Urease: Urease Inhibiters as a Significant Therapeutic Goal
نویسندگان
چکیده
Urease (urea amidohydrolase) is usually found in different bacteria, fungi, algae and plants. It is accountable for the hydrolysis of urea and thus, forming ammonia and carbamate, which is the final step of nitrogen metabolism in living organisms [1,2]. The carbamate intern quickly and spontaneously decomposes, yielding a second molecule of ammonia. These reactions may cause significant increase in pH and are therefore, responsible for negative effects of urease activity in human health and agriculture [3,4].
منابع مشابه
بازدارندگی فلزات سنگین و حلال‌ها بر آنزیم اوره‌آز برای تولید آمونیاک در سنتز داروی ضدفشار خون نیفیدیپین
Introduction: Simultaneous development of technology is composed with environmental hazardous with heavy-metals and organic solvents and thus toxic catalysts/organic solvents must be replaced with biocatalysts and water. Urease is a hydrolase enzyme and urease-urea can be considered a safe source of toxic ammonia in synthesis of nifedipine. Nifedipine is an antihypertensive drug synthesized by ...
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